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- Title
Synthesis of 4-aminoquinoline-1,2,3-triazole and 4-aminoquinoline-1,2,3-triazole-1,3,5-triazine Hybrids as Potential Antimalarial Agents.
- Authors
Manohar, Sunny; Khan, Shabana I.; Rawat, Diwan S.
- Abstract
We report herein synthesis of a series of 4-aminoquinoline-1,2,3-triazole and 4-aminoquinoline-1,2,3-triazole-1,3,5-triazine hybrids and evaluate their antimalarial activity against D6 and W2 strains of Plasmodium falciparum. To study the structure-activity relationship of substituted 4-aminoquinoline-based hybrids, 34 structurally diverse compounds were synthesized and tested against D6 and W2 strains of P. falciparum. Some of the compounds have shown promising antimalarial activity without toxicity against Vero cells. Synthesis of a series of 4-aminoquinoline-1,2,3-triazole and 4-aminoquinoline-1,2,3-triazole-1,3,5-triazine hybrids and their antimalarial activity against D6 and W2 strains of P. falciparum is reported. Some of the compounds have shown promising antimalarial activity without toxicity against Vero cells
- Subjects
TRIAZOLES; ANTIMALARIALS; PLASMODIUM falciparum; STRUCTURE-activity relationship in pharmacology; DRUG therapy for malaria
- Publication
Chemical Biology & Drug Design, 2011, Vol 78, Issue 1, p124
- ISSN
1747-0277
- Publication type
Article
- DOI
10.1111/j.1747-0285.2011.01115.x