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- Title
Preparation of Amino Alcohols Condensed with Carbohydrates: Evaluation of Cytotoxicity and Inhibitory Effect on NO Production.
- Authors
Corrêa, Taís A.; Reis, Elaine F. C.; Alves, Lívia L.; Alves, Caio C. S.; Castro, Sandra B. R.; Dias, Alyria T.; Taveira, Aline F.; Le Hyaric, Mireille; Couri, Mara R. C.; Ferreira, Ana P.; de Almeida, Mauro V.
- Abstract
This work reports the preparation of several amino alcohols condensed withd-arabinose,d-glucose, andd-galactose derivatives. These compounds were evaluated in vitro for their cytotoxicity and ability to decrease nitric oxide production in J774A.1 cells. Arabinofuranoside derivatives 5a, 5b and 5c showed a significant inhibition of nitric oxide production (>80% at 5 μg/mL), while the galactopyranoside derivative 8d showed a notable nitric oxide inhibitory activity (126% at 0.5 μg/mL).
- Subjects
AMINO alcohols; CARBOHYDRATES; NITRIC oxide; INSULIN derivatives; IN vitro toxicity testing; NITROGEN compounds
- Publication
Chemical Biology & Drug Design, 2010, Vol 76, Issue 5, p451
- ISSN
1747-0277
- Publication type
Letter
- DOI
10.1111/j.1747-0285.2010.01026.x