We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
RAS Mutations in Esophageal Squamous Papilloma.
- Authors
Sasaki, Eiichi; Matsushita, Hirokazu; Masago, Katsuhiro; Hanai, Nobuhiro
- Abstract
A recent article in the International Journal of Surgical Pathology discusses the detection of human papillomavirus (HPV) in esophageal squamous papillomas (ESPs). The authors conducted an analysis using RNA in situ hybridization (ISH) and found that none of the cases tested positive for HPV RNA ISH, leading them to conclude that HPV is unlikely to be involved in the development of ESPs. However, the authors also noted the presence of RAS mutations in ESPs, suggesting that oncogenic driver mutations may play a role in their occurrence. The article also mentions other types of papillomas in the upper aerodigestive and lower respiratory tracts that harbor oncogenic mutations in the EGFR-RAS-RAF pathway.
- Subjects
MITOGEN-activated protein kinase kinase; NUCLEIC acid hybridization; HUMAN papillomavirus; RNA analysis; GENETIC mutation
- Publication
International Journal of Surgical Pathology, 2024, Vol 32, Issue 6, p1232
- ISSN
1066-8969
- Publication type
Letter
- DOI
10.1177/10668969231216987