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- Title
LEISHMANICIDAL ACTIVITY OF Echinaster (Othilia) echinophorus CRUDE EXTRACT.
- Authors
Parra, Marley García; Fidalgo, Lianet Monzote; Martinez, Judith Mendiola; Alvarez, Ana Margarita Montalvo; Iglesias, Olga Valdé
- Abstract
In this study, a methanolic extract from Echinaster (Othilia) echinophorus was evaluated for activity against Leishmania amazonensis. The extract showed activity against the promastigote and amastigote forms with IC50 values of 62.9 and 37.5 μg.mL-1 respectively. This extract showed a moderate toxicity on macrophages from BALB/c mice. A dose of 100 mg/kg/day was effective when administered during 15 days by intraperitoneal route to BALB/c mice infected experimentally.
- Subjects
LEISHMANIA; ECHINASTERIDAE; AMASTIGOTES; TOXICITY testing; METHANOL; EXTRACTION (Chemistry); MACROPHAGES; INTRAPERITONEAL injections; LABORATORY mice; ANTIPROTOZOAL agents; SAPONINS
- Publication
Revista do Instituto de Medicina Tropical de São Paulo, 2010, Vol 52, Issue 2, p89
- ISSN
0036-4665
- Publication type
Article
- DOI
10.1590/S0036-46652010000200005