We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Regulation of Adrenoceptor and Muscarinic Receptor Gene Expression after Single and Repeated Stress.
- Authors
Myslivecek, Jaromir; Tillinger, Andrej; Novakova, Martina; Kvetňanský, Richard
- Abstract
Although stress is tightly connected with elevated levels of catecholamines, stress effects on target structures of catecholamine action—adrenoceptors (ARs)—has not been deeply studied yet. Similarly, very little is known about changes of muscarinic receptors (MRs) during stress. We determined changes in these receptors in the individual parts of the heart (right atria and ventricles) of animals (rats and mice) exposed to a single and repeated immobilization stress. Changes of tissue catecholamines, β2-AR gene expression, protein levels, and binding sites were determined in rat right ventricles, and changes in β1-, β2-, and β3-AR gene expression were followed in murine right atria. Tissue catecholamines were elevated, while β2-AR mRNA levels and β2-AR proteins and binding were decreased, in rat right ventricles. In murine right atria, β1- and β2-AR gene expression was elevated, while β3-AR mRNA levels and M2-MR were reduced. Taken together, our data show that interaction of AR and MR is important for the organism coping with stress and that different heart regions reveal distinct reactions to stress.
- Subjects
ADRENERGIC receptors; MUSCARINIC receptors; GENE expression; CATECHOLAMINES; TISSUES; MESSENGER RNA
- Publication
Annals of the New York Academy of Sciences, 2008, Vol 1148, p367
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1410.028