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- Title
Orphan Nuclear Receptor Nur77 Translocates to Mitochondria in the Early Phase of Apoptosis Induced by Synthetic: Chenodeoxycholic Acid Derivatives in Human Stomach Cancer Cell Line SNU-1.
- Authors
JEONG, JIN HEE; PARK, JOO‐SUNG; MOON, BONGKYUNG; KIM, MIN CHAN; KIM, JAE‐KON; LEE, SUNGEUN; SUH, HONGSUK; KIM, NAM DEUK; KIM, JONG‐MIN; PARK, YOUNG CHUL; YOO, YOUNG HYUN
- Abstract
Apoptosis-inducing activity of synthetic CDCA derivatives, HS-1199 and HS-1200, on gastric cancer cell line SNU-1 cells was explored. CDCA derivatives demonstrated various apoptosis hallmarks, such as mitochondrial changes, activation of caspase, DNA fragmentation, and nuclear condensation. Importantly, the orphan receptor Nur77 (TR3) was shown to translocate from the nucleus to mitochondria at the early time points after CDCA derivatives treatment. These data support the theory that CDCA derivatives-induced apoptosis of SNU-1 gastric cancer cell lines is mediated by mitochondria and caspase, and, at least in part, by Nur77.
- Subjects
APOPTOSIS; CANCER cells; CELL lines; MITOCHONDRIA; CELL culture; DNA; GENES; CELL death; ORGANELLES
- Publication
Annals of the New York Academy of Sciences, 2004, Vol 1010, Issue 1, p171
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1299.029