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- Title
Distribution of micafungin in the tissue fluids of patients with invasive fungal infections.
- Authors
Yamada, Noriaki; Kumada, Keisuke; Kishino, Satoshi; Mochizuki, Nobuo; Ohno, Keiko; Ogura, Shinji
- Abstract
The distribution of micafungin (MCFG) in tissue fluids, such as cerebrospinal fluid (CSF), pleural effusions, ascites, and wound tissue fluids, was examined in seven patients with invasive fungal infections. MCFG (100-300 mg) was administered once daily over a 1-h intravenous infusion. Blood and tissue fluid samples were collected from 1 to 24 h after infusion. Although two patients had similar MCFG concentrations in their plasma, the concentrations in the CSF differed between these two patients. The concentration in the CSF of one patient was much higher than the MIC for Candida albicans, Candida glabrata, and Aspergillus fumigatus, whereas the MCFG concentration in the CSF of the other patient was comparable to the MIC. By contrast, MCFG concentrations in pleural effusions, ascites, and wound tissue fluids were above the MIC . These results suggest that intravenous MCFG may be effective to treat invasive fungal infections that invade the organs and tissues.
- Subjects
CEREBROSPINAL fluid; PLEURAL effusions; PLEURA diseases; ASCITES; CANDIDA albicans
- Publication
Journal of Infection & Chemotherapy (Springer Science & Business Media B.V.), 2011, Vol 17, Issue 5, p731
- ISSN
1341-321X
- Publication type
Article
- DOI
10.1007/s10156-011-0240-3