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- Title
Cap-Dependent Translation Initiation Factor e IF4E: An Emerging Anticancer Drug Target.
- Authors
Jia, Yan; Polunovsky, Vitaly; Bitterman, Peter B.; Wagner, Carston R.
- Abstract
Cancer cells tend to be more highly dependent on cap-dependent translation than normal tissues. Thus, proteins involved in the initiation of cap-dependent translation have emerged as potential anti-cancer drug targets. Cap-dependent translation is initiated by the binding of the factor eIF4E to the cap domain of mRNA. Detailed x-ray crystal and NMR structures are available for eIF4E in association with cap-analogs, as well as domains of other initiation factors. This review will summarize efforts to design potential antagonist of eIF4E that could be used as new pharmacological tools and anti-cancer agents and. Insights drawn from these studies should aid in the design of future inhibitors of eIF4E dependent translation initiation. © 2012 Wiley Periodicals, Inc. Med Res Rev., 32, No. 4, 786-814, 2012
- Publication
Medicinal Research Reviews, 2012, Vol 32, Issue 4, p786
- ISSN
0198-6325
- Publication type
Article
- DOI
10.1002/med.21260