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- Title
Intra-articular injection of hyaluronate and indomethacin in rabbits with antigen-induced arthritis.
- Authors
Yow-Jen Lo; Ming-Thau Sheu; Wen-Chi Tsai; Yun-Ho Lin; Jau-Le Li; Yu-Chih Liang; Chi-Ching Chang; Ming-Shium Hsieh; Chien-Ho Chen
- Abstract
Combined effects of hyaluronate and indomethacin in the treatment of rabbits with antigen-induced arthritis (AIA) were evaluated by assessing joint swelling, C-reactive protein (CRP) and prostaglandin E2 (PGE2) levels with periodic intra-articular (ia) injections of hyaluronate alone (HA group) and with either a low or high concentration of indomethacin (LI-HA or HI-HA group). End-point analyses included matrix metalloproteinases-3 (MMP-3) activity and macroscopic and histological joint examinations. Results demonstrated that treatment in LI-HA and HI-HA groups resulted in statistically significant suppression of CRP, PGE2, and MMP-3 in comparison with those of HA group. Inhibition of serum CRP was only observed in LI-HA group. The order of serum MMP-3 inhibition was LI-HA>HI-HA>HA. Based on macroscopic and histological analyses of pannus formation, hyperplasia, inflammation, joint leakage and erosion, and loss of proteoglycan, the only statistically significant improvement was shown in LI-HA group compared to HA group and HI-HA group compared to control group.
- Subjects
PARENTERAL therapy; THERAPEUTIC use of hyaluronic acid; INDOMETHACIN; ARTHRITIS; EPITOPES; C-reactive protein; PROSTAGLANDINS; THERAPEUTICS
- Publication
Rheumatology International, 2007, Vol 27, Issue 12, p1099
- ISSN
0172-8172
- Publication type
Article
- DOI
10.1007/s00296-007-0346-1