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- Title
Cytoprotective Polyketides from Sponge-Derived Fungus Lopadostoma pouzarii.
- Authors
Trinh, Phan Thi Hoai; Yurchenko, Anton N.; Khmel, Olga O.; Dieu, Trang Vo Thi; Ngoc, Ngo Thi Duy; Girich, Elena V.; Menshov, Alexander S.; Kim, Natalya Y.; Chingizova, Ekaterina A.; Van, Tran Thi Thanh; Lee, Jong Seok; Lee, Hyi-Seung; Yurchenko, Ekaterina A.
- Abstract
The new polyketides lopouzanones A and B, as well as the new 1-O-acetyl and 2-O-acetyl derivatives of dendrodochol B, were isolated from the sponge-derived marine fungus Lopadostoma pouzarii strain 168CLC-57.3. Moreover, six known polyketides, gliorosein, balticolid, dendrodolide G, dihydroisocoumarine, (–)-5-methylmellein, and dendrodochol B, were identified. The structures of the isolated compounds were determined by a combination of NMR and ESIMS techniques. The absolute configurations of the lopouzanones A and B were determined using the Mosher's method. The cytotoxicity of the isolated compounds against human prostate cancer cells PC-3 and normal rat cardiomyocytes H9c2 was investigated. Gliorosein showed weak DPPH radical-scavenging activity and in vitro cardioprotective effects toward rotenone toxicity and CoCl2-mimic hypoxia.
- Subjects
POLYKETIDES; MARINE fungi; ROTENONE; FUNGI; CANCER cells; PROSTATE cancer
- Publication
Molecules, 2022, Vol 27, Issue 21, p7650
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27217650