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- Title
Synthesis, Antibacterial and Anthelmintic Activity of Novel 3-(3-Pyridyl)-oxazolidinone-5-methyl Ester Derivatives.
- Authors
Jin, Bo; Chen, Jia-yi; Sheng, Zun-lai; Sun, Meng-qing; Yang, Hong-liang
- Abstract
In this study, a series of 3-(3-pyridyl)-oxazolidone-5-methyl ester derivatives was synthesized and characterized by 1H NMR, 13C NMR, and LC-MS. The conducted screening antibacterial studies of the new 3-(3-pyridyl)-oxazolidone-5-methyl ester derivatives established that the methyl sulfonic acid esters have broad activity spectrum towards Staphylococcus aureus, Streptococcus pneumoniae, Bacillus subtilis and Staphylococcus epidermidis. Among them, compound 12e has the most potent activity, with an MIC of 16 μg/mL against B.subtilis, and could reduce the instantaneous growth rate of bacteria. Furthermore, molecular docking studies were also simulated for compound 12e to predict the specific binding mode of this compound. In addition, anthelmintic activity of these compounds was also evaluated against adult Indian earthworms (Pheretima posthuman). The results showed that compound 11b had the best effect. These results above can provide experimental reference for the development of novel antibacterial and anthelmintic drugs.
- Subjects
ESTER derivatives; OXAZOLIDINONES; ANTIBACTERIAL agents; STAPHYLOCOCCUS epidermidis; SULFONIC acids; STREPTOCOCCUS pneumoniae
- Publication
Molecules, 2022, Vol 27, Issue 3, p1103
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27031103