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- Title
Napthrene Compounds from Mycelial Fermentation Products of Marasmius berteroi.
- Authors
Yang, Ning Ning; Ma, Qing Yun; Kong, Fan Dong; Xie, Qing Yi; Dai, Hao Fu; Zhou, Li Man; Yu, Zhi Fang; Zhao, You Xing
- Abstract
The metabolites of the genus Marasmius are diverse, showing good research prospects for finding new bioactive molecules. In order to explore the active metabolites of the fungi Marasmius berteroi, the deep chemical investigation on the bioactive compounds from its cultures was undertaken, which led to the isolation of three new naphthalene compounds dipolynaphthalenes A–B (1,2) and naphthone C (3), as well as 12 known compounds (4–15). Compounds 1, 2, and 4 are dimeric naphthalene compounds. Their structures were elucidated by MS, 1D and 2D NMR spectroscopic data, as well as ECD calculations. Compounds 2–4 and 7 exhibited acetylcholinesterase (AChE) inhibitory activities at the concentration of 50 μg/mL with inhibition ratios of 42.74%, 44.63%, 39.50% and 51.49%, respectively. Compounds 5 and 7,8 showed weak inhibitory activities towards two tumor cell lines, with IC50 of 0.10, 0.076 and 0.058 mM (K562) and 0.13, 0.18, and 0.15 mM (SGC-7901), respectively.
- Subjects
INHIBITORY Concentration 50; BIOACTIVE compounds; ACETYLCHOLINESTERASE; CELL lines
- Publication
Molecules, 2020, Vol 25, Issue 17, p3898
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25173898