We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Synthesis and Evaluation of New Potential Benzo[a]phenoxazinium Photosensitizers for Anticancer Photodynamic Therapy.
- Authors
Zhang, Juan; Tavares de Sousa Júnior, Wellington; Mello da Silva, Victor Carlos; Rodrigues, Mosar Correa; Vasconcelos Morais, José Athayde; Song, Jia-Li; Cheng, Zhi-Qiang; Longo, João Paulo Figueiró; Bentes Azevedo, Ricardo; Jiang, Cheng-Shi; Alexandre Muehlmann, Luís; Zhang, Hua
- Abstract
The use of photodynamic therapy (PDT) and development of novel photosensitizers (PSs) for cancer treatment have received more and more attention nowadays. In the present work, five benzo[<italic>a</italic>]phenoxazinium derivatives have been prepared and evaluated for their in vitro anticancer photodynamic activity for the first time. They are red light absorbers and show low fluorescence quantum yield. Of these compounds, <bold>PS4</bold> exhibited a higher quantum yield for reactive oxygen species (ROS) generation. The assays with cells in vitro showed that <bold>PS1</bold> and <bold>PS4</bold> were not significantly toxic in the dark, but was robustly toxic against the murine breast adenocarcinoma cells 4T1 and normal murine fibroblast cells NIH-3T3 upon photoactivation. More interestingly, <bold>PS5</bold> was particularly selective towards 4T1 cancer cells and nearly non-phototoxic to non-cancerous NIH-3T3 cells. The results described in this report suggest that these new benzo[<italic>a</italic>]phenoxazinium derivatives are potential candidates as PSs for anticancer PDT. Further investigation of benzo[<italic>a</italic>]phenoxaziniums for anticancer PDT is warranted.
- Subjects
BREAST cancer treatment; PHOTOSENSITIZERS; ANTINEOPLASTIC agents; REACTIVE oxygen species; FIBROBLASTS
- Publication
Molecules, 2018, Vol 23, Issue 6, p1436
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules23061436