We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
A Multi-Target Approach toward the Development of Novel Candidates for Antidermatophytic Activity: Ultrastructural Evidence on α-Bisabolol-Treated Microsporum gypseum.
- Authors
Romagnoli, Carlo; Baldisserotto, Anna; Malisardi, Gemma; Vicentini, Chiara B.; Mares, Donatella; Andreotti, Elisa; Vertuani, Silvia; Manfredini, Stefano
- Abstract
Multi-target strategies are directed toward targets that are unrelated (or distantly related) and can create opportunities to address different pathologies. The antidermatophytic activities of nine natural skin lighteners: α-bisabolol, kojic acid, β-arbutin, azelaic acid, hydroquinone, nicotinamide, glycine, glutathione and ascorbyl tetraisopalmitate, were evaluated, in comparison with the known antifungal drug fluconazole, on nine dermatophytes responsible for the most common dermatomycoses: Microsporum gypseum, Microsporum canis, Trichophyton violaceum, Nannizzia cajetani, Trichophyton mentagrophytes, Epidermophyton floccosum, Arthroderma gypseum, Trichophyton rubrum and Trichophyton tonsurans. α-Bisabolol showed the best antifungal activity against all fungi and in particular; against M. gypseum. Further investigations were conducted on this fungus to evaluate the inhibition of spore germination and morphological changes induced by α-bisabolol by TEM.
- Subjects
MICROSPORUM; FADE creams (Cosmetics); ARBUTIN; HYDROQUINONE; NICOTINAMIDE; GLYCINE; GLUTATHIONE
- Publication
Molecules, 2015, Vol 20, Issue 7, p11765
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules200711765