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- Title
New and Cytotoxic Components from Antrodia camphorata.
- Authors
Tzong-Huei Lee; Chien-Chih Chen; Jih-Jung Chen; Hui-Fen Liao; Hsun-Shuo Chang; Ping-Jyun Sung; Mei-Hwei Tseng; Sheng-Yang Wang; Horng-Huey Ko; Yueh-Hsiung Kuo
- Abstract
The solid-state cultured products of Antrodia camphorata as health foods has been blooming for the past few decades in Taiwan. In continuing our studies on the chemical constituents of the solid-state cultured products of this fungus, 6-methoxy-4-methyl-2,3- (methylenedioxy)phenol (1) and 4,4'-(ethane-1,2-diyl)bis(2,3,6-trimethoxyphenol)(2) together with 2,3,6-trimethoxy-4-methylphenol (3), 1(10→6)abeo-ergosta-5,7,9,22-tetraen-3α-ol (4), citreoanthrasteroid B (5) and dankasterones A (6) and B (7) were purified by a series of column chromatography. Their structures were elucidated by spectral data analysis. For bioactivity assay, compounds 4-7 showed significant cytotoxicity toward murine colorectal CT26 and human leukemia K562 cancer cell lines with IC50 values ranging from 6.7 to 15.3 μM and from 12.5 to 23.1 μM, respectively.
- Subjects
NATURAL foods; CELLULAR pathology; CELL lines; CANCER cell enzymes; CANCER cell differentiation; ANTRODIAETUS
- Publication
Molecules, 2014, Vol 19, Issue 12, p21378
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules191221378