We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Resveratrol and Endothelial Nitric Oxide.
- Authors
Ning Xia; Förstermann, Ulrich; Huige Li
- Abstract
Nitric oxide (NO) derived from the endothelial NO synthase (eNOS) has antihypertensive, antithrombotic, anti-atherosclerotic and antiobesogenic properties. Resveratrol is a polyphenol phytoalexin with multiple cardiovascular and metabolic effects. Part of the beneficial effects of resveratrol are mediated by eNOS. Resveratrol stimulates NO production from eNOS by a number of mechanisms, including upregulation of eNOS expression, stimulation of eNOS enzymatic activity and reversal of eNOS uncoupling. In addition, by reducing oxidative stress, resveratrol prevents oxidative NO inactivation by superoxide thereby enhancing NO bioavailability. Molecular pathways underlying these effects of resveratrol involve SIRT1, AMPK, Nrf2 and estrogen receptors.
- Subjects
RESVERATROL; NITRIC oxide; NITRIC-oxide synthases; POLYPHENOLS; PHYTOALEXINS; OXIDATIVE stress; BIOAVAILABILITY; ESTROGEN receptors
- Publication
Molecules, 2014, Vol 19, Issue 10, p16102
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules191016102