We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Synthesis and Anti-TMV Activity of Dialkyl/dibenzyl 2-((6-Substituted-benzo[d]thiazol-2- ylamino)(benzofuran-2-yl)methyl) Malonates.
- Authors
Han Xiao; Pengcheng Zheng; Chenghao Tang; Ying Xie; Fang Wu; Jie Song; Jun Zhao; Zhining Li; Meichuan Li
- Abstract
Starting from benzofuran-2-methanal, 6-substituted benzothiazole-2-amines and malonic esters, sixteen title compounds were designed and synthesized seeking to introduce anti-TMV activity. The structures of the newly synthesized compounds were confirmed by 1H-NMR, 13C-NMR, IR spectra, and MS (HREI) analysis. The bioassays identified some of these new compounds as having moderate to good anti-TMV activity. The compounds 5i and 5m have good antiviral activity against TMV with a curative rate of 52.23% and 54.41%, respectively, at a concentration of 0.5 mg/mL.
- Subjects
TOBACCO mosaic virus; BENZOFURANS; BENZOTHIAZOLE; MALONATES; NUCLEAR magnetic resonance; BIOLOGICAL assay; ANTIVIRAL agents
- Publication
Molecules, 2013, Vol 18, Issue 11, p13623
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules181113623