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- Title
Antileishmanial Activity of the Hydroalcoholic Extract of Miconia langsdorffii, Isolated Compounds, and Semi-Synthetic Derivatives.
- Authors
Peixoto, Juliana A.; e Silva, Márcio Luis Andrade; Crotti, Antônio E. M.; Veneziani, Rodrigo Cassio Sola; Gimenez, Valéria M. M.; Januário, Ana H.; Groppo, Milton; Magalhães, Lizandra G.; dos Santos, Fransérgio F.; Albuquerque, Sérgio; da Silva Filho, Ademar A.; Cunha, Wilson R.
- Abstract
The in vitro activity of the crude hydroalcoholic extract of the aerial parts of Miconia langsdorffii Cogn. was evaluated against the promastigote forms of L. amazonensis, the causative agent of cutaneous leishmaniasis in humans. The bioassayguided fractionation of this extract led to identification of the triterpenes ursolic acid and oleanolic acid as the major compounds in the fraction that displayed the highest activity. Several ursolic acid semi-synthetic derivatives were prepared, to find out whether more active compounds could be obtained. Among these ursolic acid-derived substances, the C-28 methyl ester derivative exhibited the best antileishmanial activity.
- Subjects
MICONIA calvescens; LEISHMANIASIS; PROTOZOAN diseases; MICONIA (Genus); PARASITIC diseases
- Publication
Molecules, 2011, Vol 16, Issue 2, p1825
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules16021825