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- Title
Impact of body mass index, smoking habit, alcohol consumption, physical activity and parity on disease course of women with triple-negative breast cancer.
- Authors
Schmidt, Gilda; Schneider, Christina; Gerlinger, Christoph; Endrikat, Jan; Gabriel, Lena; Ströder, Russalina; Müller, Carolin; Juhasz-Böss, Ingolf; Solomayer, Erich-Franz
- Abstract
<bold>Objective: </bold>To evaluate the potential impact of body mass index (BMI), smoking habit, alcohol consumption, physical activity and parity on disease course of women with triple-negative breast cancer (TNBC).<bold>Material and Methods: </bold>This was a retrospective chart analysis of patients with TNBC. Primary target parameters were overall survival (OS) and disease-free survival (DFS) depending on BMI, smoking habit, alcohol consumption, physical activity and parity. Results were descriptively evaluated and plotted as Kaplan-Meier curves. The null hypothesis was tested using the non-parametric log-rank test. All patients were treated at the University Medical School of Saarland, Dept of Gynecology, Obstetrics and Reproductive Medicine.<bold>Results: </bold>A total of 197 patients were analyzed. More than 50% of women were 40-60 years old (mean 57 years) and had a normal BMI. More than 88% of patients had either a T1 or T2 tumor, 64% were N0 and 66.5% had a G3 cancer. Thirty-four of 84 patients (40.38%) on neo-adjuvant chemotherapy reached a pathology-confirmed complete remission. During the follow-up (median 41.43 months), 34 (17.3%) patients had recurrent disease and 51 (25.9%) suffered from metastases. A total of 51 (25.9%) finally deceased. OS and DFS were not significantly impacted by BMI (OS: p = 0.4720; DFS: p = 0.2272), smoking habit (p = 0.9892; p = 0.6040), alcohol consumption (p = 0.6515; p = 0.7460), physical activity (p = 0.3320; p = 0.5991) or parity (p = 0.5929; 0.1417).<bold>Conclusion: </bold>BMI, smoking habit, alcohol consumption, physical activity and parity had no impact on OS or DFS in women with TNBC.
- Subjects
SAARLAND (Germany); TRIPLE-negative breast cancer; BODY mass index; BREAST cancer; ALCOHOL drinking; PHYSICAL activity; NON-communicable diseases
- Publication
Archives of Gynecology & Obstetrics, 2020, Vol 301, Issue 2, p603
- ISSN
0932-0067
- Publication type
journal article
- DOI
10.1007/s00404-019-05413-4