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- Title
Growth hormone secretagogue peptide A233 upregulates Mx expression in teleost fish in vitro and in vivo.
- Authors
Martinez, Rebeca; Fernández-Trujillo, María Alejandra; Hernández, Liz; Page, Adrian; Béjar, Julia; Estrada, Mario Pablo
- Abstract
Aquaculture constitutes an alternative source for food production and contributes to a reduction in the indiscriminate catching of aquatic organisms in their natural environment. However, high mortality during the larval state remains a challenge in this sector, mainly because of factors such as diet and diseases caused by pathogens. Therefore, growth and health management is a key strategy for sustainable aquaculture. Synthetic growth hormone secretagogues (GHSs) are a family of ligands that can stimulate pituitary growth hormone release as well as the function of ghrelin, contributing to the immune responses in a variety of vertebrates, including fish. The A233 decapeptide is a GHS with a demonstrated impact on growth, immune system function, and antioxidant defense in tilapia fish, but no antiviral activity has been described for this peptide. Here, using an in vitro model (TRG-2 cells) and two in vivo models (sea bream [Sparus aurata]) and zebrafish [Danio rerio]), we demonstrate for the first time the potential antiviral effect of A233 in teleost fish.
- Subjects
PEPTIDE hormones; SOMATOTROPIN receptors; SOMATOTROPIN; GHRELIN receptors; SPARUS aurata; SUSTAINABLE aquaculture; PEPTIDES
- Publication
Archives of Virology, 2022, Vol 167, Issue 10, p2041
- ISSN
0304-8608
- Publication type
Article
- DOI
10.1007/s00705-022-05504-9