We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Anti-Ischemic Activity of n-Tyrozol under Conditions of Repeated Transient Myocardial Ischemia in Rats.
- Authors
Plotnikov, M. B.; Chernysheva, G. A.; Smol'yakova, V. I.; Plotnikova, T. M.; Sysolyatin, S. V.; Kryukov, Y. A.
- Abstract
We studied anti-ischemic activity of n-tyrozol under conditions of repeated transient myocardial ischemia in rats caused by repeated (5×3 min) occlusion of the left coronary artery. n-Tyrozol administered intraperitoneally in a dose of 20 mg/kg daily over 4 days before the ischemia modeling (the last injection 15 min prior to the start of the experiment) produced a clear-cut anti-ischemic effect: it reduced ST elevation and promoted more complete recovery of ECG during reperfusion. During reperfusion periods, n-tyrozol significantly decreased the risk of ventricular fibrillation and shortened the duration of tachyarrhythmia episodes (ventricular tachycardia and fibrillation).
- Subjects
LABORATORY rats; CORONARY disease; ISCHEMIA; TYROSOL; CEREBRAL ischemia
- Publication
Bulletin of Experimental Biology & Medicine, 2018, Vol 165, Issue 5, p625
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-018-4228-1