We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Studying the Role of DNA Repair Gene Polymorphism in Formation of Predisposition to Lung Cancer Development in Women.
- Authors
Titov, R. A.; Minina, V. I.; Torgunakova, A. V.; Buslaev, V. Yu.; Voronina, E. N.; Prosekov, A. Yu.; Titov, V. A.; Glushkov, A. N.
- Abstract
The study involved 522 women of Russian nationality living in Kemerovo oblast of Russia, including 273 patients with lung cancer and 249 women of a similar age with no signs of cancer. Comparative analysis of polymorphic variants of DNA repair genes APEX1 444T>G (rs1130409), XRCC1 1839G>A (rs25489), hOGG1 977C>G (rs1052133), XPD 2251Т>G (rs13181), XPG 3310G>C (rs17655), and XPC 2815A>C (rs2228001) in patients with lung cancer and individuals without cancer living in the same area was performed. Analysis of single-locus effects showed significant associations between the risk of lung cancer and variants of the XPC 2815A>C gene (rs2228001) (OR = 0.56, CI: 0.39–0.81, p = 0.0018) in the general group, the APEX1 444T>G gene (rs1130409) (OR = 0.15, CI: 0.03–0.67, p = 0.0027) in the group of smokers, and genes XPC 2815A>C (rs2228001) (OR = 0.36, CI: 0.18–0.69, p = 0.0051) and hOGG1 977C>G (rs1052133) (OR = 0.57, CI: 0.38–0.85, p = 0.0055) in the group of nonsmokers. MDR analysis of gene-gene interactions showed that genes XPD 2251Т>G and XPC 2815A>C, APEX1 444T>G, and XPD 2251Т>G closely interact and mutually increase the risk of lung cancer in women of Western Siberia.
- Subjects
KEMEROVO (Russia); RUSSIA; DNA repair; LUNG cancer; GENETIC polymorphisms; CANCER patients; CARCINOGENESIS
- Publication
Russian Journal of Genetics, 2022, Vol 58, Issue 2, p194
- ISSN
1022-7954
- Publication type
Article
- DOI
10.1134/S1022795422020132