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- Title
Meiotic recombination in mammals: localization and regulation.
- Authors
Baudat, Frédéric; Imai, Yukiko; de Massy, Bernard
- Abstract
During meiosis, a programmed induction of DNA double-strand breaks (DSBs) leads to the exchange of genetic material between homologous chromosomes. These exchanges increase genome diversity and are essential for proper chromosome segregation at the first meiotic division. Recent findings have highlighted an unexpected molecular control of the distribution of meiotic DSBs in mammals by a rapidly evolving gene, PR domain-containing 9 (PRDM9), and genome-wide analyses have facilitated the characterization of meiotic DSB sites at unprecedented resolution. In addition, the identification of new players in DSB repair processes has allowed the delineation of recombination pathways that have two major outcomes, crossovers and non-crossovers, which have distinct mechanistic roles and consequences for genome evolution.
- Subjects
MEIOSIS; GENETICS; KARYOKINESIS; CROSSING over (Genetics); CELL division
- Publication
Nature Reviews Genetics, 2013, Vol 14, Issue 11, p794
- ISSN
1471-0056
- Publication type
Article
- DOI
10.1038/nrg3573