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- Title
Klinefelter's syndrome associated with systemic lupus erythematosus and autoimmune hepatitis.
- Authors
Sasaki, Nobuhito; Yamauchi, Kohei; Sato, Ryo; Masuda, Tomoyuki; Sawai, Takashi; Inoue, Hiroshi
- Abstract
Klinefelter's syndrome (KFS) tends to be associated with immunological disorders. We describe a 37-year-old man who presented signs of testicular atrophy and decreased body hair. He showed pancytopenia and elevated levels of liver enzymes. Chromosome analysis revealed 47XXY karyotype; therefore, he was diagnosed with KFS, with systemic lupus erythematosus and autoimmune hepatitis. Treatment with a high dose of methylprednisolone and methyltestosterone improved thrombocytopenia and symptoms, suggesting that methyltestosterone may have a clinical benefit in the treatment of KFS with a low level of testosterone accompanying immunological disorders.
- Subjects
KLINEFELTER'S syndrome; SYSTEMIC lupus erythematosus; CHRONIC active hepatitis; IMMUNOLOGIC diseases; ENZYMES
- Publication
Modern Rheumatology, 2006, Vol 16, Issue 5, p305
- ISSN
1439-7595
- Publication type
Article
- DOI
10.3109/s10165-006-0511-5