We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
A functional chicken‐liver hydrolysate‐based supplement ameliorates alcohol liver disease via regulation of antioxidation, anti‐inflammation, and antiapoptosis.
- Authors
Wu, Yi‐Hsieng Samuel; Lin, Yi‐Ling; Kao, Yi‐Feng; Chen, Jr‐Wei; Chen, Yi‐Chou; Chen, Yi‐Chen
- Abstract
Tons of broiler livers are produced yearly in Taiwan but always considered waste. Our team has successfully patented and characterized a chicken‐liver hydrolysate (CLH) with several biofunctions. Chronic alcohol consumption causes hepatosteatosis or even hepatitis, cirrhosis, and cancers. This study was to investigate the hepatoprotection of CLH‐based supplement (GBHP01™) against chronic alcohol consumption. Results showed that GBHP01™ could reduce (p <.05) enlarged liver size, lipid accumulation/steatosis scores, and higher serum AST, ALT, γ‐GT, triglyceride, and cholesterol levels induced by an alcoholic liquid diet. GBHP01™ reduced liver inflammation and apoptosis in alcoholic liquid‐diet‐fed mice via decreasing TBARS, interleukin‐6, interleukin‐1β, and tumor necrosis factor‐α levels, increasing reduced GSH/TEAC levels and activities of SOD, CAT and GPx, as well as downregulating CYP2E1, BAX/BCL2, Cleaved CASPASE‐9/Total CASPASE‐9 and Active CASPASE‐3/Pro‐CASPASE‐3 (p <.05). Furthermore, GBHP01™ elevated hepatic alcohol metabolism (ADH and ALDH activities) (p <.05). In conclusion, this study prove the hepatoprotection of GBHP01™ against alcohol consumption.
- Subjects
TAIWAN; LIVER diseases; HEPATOMEGALY; ALCOHOL drinking; HEPATITIS; CYTOCHROME P-450 CYP2E1; ASPARTATE aminotransferase
- Publication
Environmental Toxicology, 2024, Vol 39, Issue 3, p1759
- ISSN
1520-4081
- Publication type
Article
- DOI
10.1002/tox.24072