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- Title
Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins.
- Authors
Tomita, Susumu; Lu Chen; Kawasaki, Yoshimi; Petralia, Ronald S.; Wenthold, Robert J.; Nicoll, Roger A.; Bredt, David S.
- Abstract
Functional expression of α-amino-3-hydroxy-5-methyl 4-isoxazolepropionic acid (AMPA) receptors in cerebellar granule cells requires stargazin, a member of a large family of four-pass transmembrane proteins. Here, we define a family of transmembrane AMPA receptor regulatory proteins (TARPs), which comprise stargazin, γ-3, γ-4, and γ-8, but not related proteins, that mediate surface expression of AMPA receptors. TARPs exhibit discrete and complementary patterns of expression in both neurons and glia in the developing and mature central nervous system. In brain regions that express multiple isoforms, such as cerebral cortex, TARP-AMPA receptor complexes are strictly segregated, suggesting distinct roles for TARP isoforms. TARPs interact with AMPA receptors at the postsynaptic density, and surface expression of mature AMPA receptors requires a TARP. These studies indicate a general role for TARPs in controlling synaptic AMPA receptors throughout the central nervous system.
- Subjects
PROPIONIC acid; MEMBRANE proteins
- Publication
Journal of Cell Biology, 2003, Vol 161, Issue 4, p805
- ISSN
0021-9525
- Publication type
Article
- DOI
10.1083/jcb.200212116