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- Title
10-mer and 9-mer WALK Peptides with Both Antibacterial and Anti-Inflammatory Activities.
- Authors
Kim, Su-Jin; Kang, Tae-Bong; Kim, Dong-Hyuk; Keum, Minho; Lee, Sung-Hee; Kim, Ji-Hun; Lee, Sang-Hyuck; Kim, Jihoon; Kweon, Hyuk-Jung; Park, Jae-Won; Kim, Beom-Jun; Won, Hyung-Sik
- Abstract
Natural antimicrobial peptides (AMPs) are multifunctional host defense peptides (HDPs) that are valuable for various therapeutic applications. In particular, natural and artificial AMPs with dual antibacterial immunomodulatory functions emerged as promising candidates for the development of therapeutic agents to treat infectious inflammation. In an effort to develop useful AMP variants with short lengths and simple amino acid composition, we devised a de novo design strategy to generate a series of model peptide isomer sequences, named WALK peptides, i.e., tryptophan (W)-containing amphipathic-helical (A) leucine (L)/lysine (K) peptides. Here, we generated two groups of WALK peptide isomers: W2L4K4 (WALK244.01~WALK244.10) and W2L4K3 (WALK243.01~WALK243.09). Most showed apparent antibacterial activities against both Gram-positive and Gram-negative bacteria at a concentration of approximately 4 μg/mL along with varied hemolytic activities against human red blood cells. In addition, some exhibited significant anti-inflammatory activities without any significant cytotoxicity in macrophages. Collectively, these results suggest that the two selected peptides, WALK244.04 and WALK243.04, showed promise for the development of antibacterial and anti-inflammatory agents.
- Subjects
ANTIMICROBIAL peptides; ANTI-inflammatory agents; PEPTIDES; ANTIBACTERIAL agents; PEPTIDE antibiotics; ERYTHROCYTES
- Publication
Antibiotics (2079-6382), 2022, Vol 11, Issue 11, p1588
- ISSN
2079-6382
- Publication type
Article
- DOI
10.3390/antibiotics11111588