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- Title
Techniques for Screening Translation Inhibitors.
- Authors
Osterman, Ilya A.; Bogdanov, Alexey A.; Dontsova, Olga A.; Sergiev, Petr V.
- Abstract
The machinery of translation is one of the most common targets of antibiotics. The development and screening of new antibiotics usually proceeds by testing antimicrobial activity followed by laborious studies of the mechanism of action. High-throughput methods for new antibiotic screening based on antimicrobial activity have become routine; however, identification of molecular targets is usually a challenge. Therefore, it is highly beneficial to combine primary screening with the identification of the mechanism of action. In this review, we describe a collection of methods for screening translation inhibitors, with a special emphasis on methods which can be performed in a high-throughput manner.
- Subjects
ANTI-infective agents; ANTIBIOTICS; DRUG development; HIGH throughput screening (Drug development); ENZYME inhibitors; BACTERIAL ribosomes
- Publication
Antibiotics (2079-6382), 2016, Vol 5, Issue 3, p22
- ISSN
2079-6382
- Publication type
Article
- DOI
10.3390/antibiotics5030022