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- Title
骨小梁评分在2型糖尿病患者中评价骨质量的应用.
- Authors
张翠平; 陈琳; 徐碧林; 朱英倩; 申甜; 朱近悦; 夏娟; 陆明; 汪红平; 陈诚; 沙雯君; 雷涛
- Abstract
Objective This study aimed to evaluate the ability of lumbar spine trabecular bone score (TBS) to assess bone quality in T2DM patients. Methods In this retrospective cross-sectional study, bone mineral density (BMD) of the lumbar spine was measured in 128 T2DM patients and 64 non-T2DM patients using DXA. TBS was calculated by examining pixel variations within the DXA images using TBS iNsight software. The differences of BMD and TBS between the two groups were analyzed. The correlation between TBS and BMD, age, and body weight was also analyzed. Results Compared with that in patients without T2DM, lumbar spine BMD increased (0.9103 ± 0.1742 vs 0.8382 ± 0.1422, P=0.005), and lumbar spine TBS decreased (1.2787 ± 0.122 vs 1.3166 ± 0.1016, P=0.033) in patients with T2DM. After adjusting data for BMI, age, and BMD, a significant difference was also observed in lumbar spine TBS (P<0.001). Results of correlation analyses showed that TBS was negatively correlated with age (r=-0.395, P<0.001) and BMI (r=-0.270, P<0.001), but was positively correlated with BMD. The association was weaker in T2DM patients than in non-T2DM patients (r=0.563, P<0.001 vs r=0.766, P<0.001). Conclusion The decreased lumbar spine TBS in T2DM patients is consistent with the high fracture risk in these patients. TBS may assist the assessment of the bone quality in T2DM patients.
- Publication
Chinese Journal of Osteoporosis, 2020, Vol 26, Issue 7, p1028
- ISSN
1006-7108
- Publication type
Article
- DOI
10.3969/j.issn.1006-7108.2020.07.019