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- Title
Analysis of Long-Term Depression in the Purkinje Cell Circuit (a Model Study).
- Authors
Zhang, X.; Liu, S.; Ren, H.; Zeng, Y.; Zhan, G.
- Abstract
In the cerebellum, long-term depression (LTD) plays a key function in sculpting neuronal circuits to store information, since motor learning and memory are thought to be associated with such long-term changes in synaptic efficacy. To better understand the principles of transmission of information in the cerebellum, we, in our model, distinguished different types of neurons (type 1- and type 2-like) to examine the neuronal excitability and analyze the interspike interval (ISI) bifurcation phenomenon in these units, and then built a Purkinje cell circuit to study the impact of external stimulation on LTD in this circuit. According to the results of computational analysis, both climbing fiber-Purkinje cell and granule cell-Purkinje cell circuits were found to manifest LTD; the external stimuli would influence LTD by changing both depression time and depression intensity. All of the simulated results showed that LTD is a very significant factor in the Purkinje circuit networks. Finally, to deliver the learning regularities, we simulated spike timing-dependent plasticity (STDP) by increasing the CaP conductance.
- Subjects
LONG-term synaptic depression; PURKINJE cells; CEREBELLUM physiology; NEURAL circuitry; MOTOR ability; COMPUTATIONAL neuroscience
- Publication
Neurophysiology, 2014, Vol 46, Issue 1, p25
- ISSN
0090-2977
- Publication type
Article
- DOI
10.1007/s11062-014-9402-0