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- Title
Study of transcranial Doppler flow grades of thrombolysis in brain ischemia in patients with acute middle cerebral artery occlusion after alteplase treatment.
- Authors
ZHOU Chen; ZHANG Pei-lan
- Abstract
To investigate the relationship between changes of blood flow of acute middle cerebral artery (MCA) occlusion or stenosis and degree of neural function defect and prognosis before and after intravenous thrombolytic therapy with alteplase. Methods Fifty-three patients diagnosed as acute MCA stenosis or occlusion and given alteplase intravenous thrombolysis therapy were enrolled. Thrombolysis in brain ischemia (TIBI) flow grades of MCA before and 24 h after the thrombolysis were assessed. The correlation between TIBI flow grades and National Institute of Health Stroke Scale (NIHSS) scores and modified Rankin Scale (mRS) scores 90 d after the thrombolysis was evaluated. Results There were significant differences in the NIHSS scores before intravenous thrombolytic therapy among different TIBI flow grades (H = 36.514, P = 0.000). The TIBI flow grade was negatively correlated with the NIHSS scores before thrombolysis (rs = -0.737, P = 0.000), indicating that lower TIBI grade of MCA presented the nerve function defect worse. Compared with before thrombolytic therapy, there were 25 cases (47.17% ) achieved to grade 4-5 of TIBI flow grade of MCA 24 h after thrombolytic therapy, suggesting the recanalization of MCA (Z = 5.262, P = 0.000). In comparision with pre-thrombolytic therapy, neural function of 38 cases (71.70% ) recovered well 24 h after treatment, and the difference of NIHSS scores was statistically significant while that of 15 cases (28.30%) did not obtain favorable recovery of neural function
- Subjects
BRAIN disease treatment; ISCHEMIA treatment; CARDIOVASCULAR disease treatment; THROMBOSIS; STENOSIS; ARTERIAL occlusions; CEREBRAL arteries; NEUROSURGERY; NEUROLOGY; TISSUE plasminogen activator; ULTRASONIC imaging; DISEASE relapse; DIAGNOSIS; THERAPEUTICS
- Publication
Chinese Journal of Contemporary Neurology & Neurosurgery, 2013, Vol 13, Issue 9, p792
- ISSN
1672-6731
- Publication type
Article
- DOI
10.3969/j.issn67.122013.09.0126731