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- Title
Effect of Coenzyme Q10 replacement on learning and memory performance in young rats.
- Authors
POLAT, Can; EROL, Meltem; BOSTAN GAYRET, Özlem; YİĞİT, Özgül; ÖZEL, Abdulrahman; ÖZCAN, Esra; METE, Fatih
- Abstract
Objective: Coenzyme Q10 (CoQ10) administration is known to increase CoQ10 concentrations in the mitochondria of brain cells and facilitate the memory and learning processes in rats. This study aims to evaluate the effects of CoQ10 treatment on learning and memory functions in rat pups during early stages of development. Methods: A total of 21-day-old 24 pups were divided into 3 groups (8 pups in each group). A low dose of CoQ10 was administered via oral gavage once per day to one group, a high dose was administered to another group, and olive oil was administered to the control group. The cognitive and learning functions of rats in these groups were evaluated by the Morris water maze and probe tests. Results: Coenzyme Q10 administration was continued for 10 days. At the end of the 37th day, the water maze test was used to evaluate learning and memory performance. No difference was observed in the test results among the high-dose, low-dose and control groups during the 5 days of training in the water maze test (p>0.05). Data from the probe trial indicated no statistically significant differences among rats that received high-, or low-dose CoQ10 or olive oil (control) (p=0.853). Conclusion: In our study, it was determined that administration of high-, or low-dose CoQ10 during childhood does not have a significant effect on learning and memory functions.
- Subjects
MAZE tests; UBIQUINONES; LEARNING in animals; ANIMAL memory
- Publication
Journal of Dr. Behcet Uz Children's Hospital, 2018, Vol 8, Issue 3, p217
- ISSN
2146-2372
- Publication type
Article
- DOI
10.5222/buchd.2018.15986