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- Title
Efficacy of every-other-day administration of conjugated equine estrogen and medroxyprogesterone acetate on gonadotropin-releasing hormone agonists treatment in women with endometriosis.
- Authors
Irahara, Minoru; Uemura, Hirokazu; Yasui, Toshiyuki; Kinoshita, Hiromi; Yamada, Masayo; Tezuka, Michiko; Kiyokawa, Machiko; Kamada, Masaharu; Aono, Toshihiro; Irahara, M; Uemura, H; Yasui, T; Kinoshita, H; Yamada, M; Tezuka, M; Kiyokawa, M; Kamada, M; Aono, T
- Abstract
We performed a randomized controlled study to determine the efficacy of add-backed therapy by every-other-day administration of 0.625 mg conjugated equine estrogen (CEE) and 2.5 mg medroxyprogesterone acetate (MPA) on GnRH agonists (GnRH-a) treatment in Japanese women with symptomatic endometriosis. At the end of treatment, serum estrone and estradiol levels in the add-back group (n = 11) were significantly higher than those in the control group (n = 10). The assessment of Beecham classification by bimanual examination, serum CA-125 levels, and the frequency of genital bleeding revealed no significant differences between the two groups. The add-back group showed reduced Kupperman indices relative to those of the control group, and could prevent the loss of bone density. These findings led to a conclusion that GnRH-a therapy added back by every-other-day administration of 0.625 mg CEE and 2.5 mg MPA was a safe and effective treatment for Japanese women with endometriosis.
- Subjects
BONE remodeling; ANIMAL experimentation; COMPARATIVE studies; ENDOMETRIOSIS; ESTRADIOL; ESTROGEN; HORSES; GONADOTROPIN releasing hormone; RESEARCH methodology; MEDICAL cooperation; MEDROXYPROGESTERONE; RESEARCH; STATISTICAL sampling; STEROIDS; TUMOR antigens; UTERINE hemorrhage; EVALUATION research; BONE density; RANDOMIZED controlled trials; LEUPROLIDE
- Publication
Gynecologic & Obstetric Investigation, 2001, Vol 52, Issue 4, p217
- ISSN
0378-7346
- Publication type
journal article
- DOI
10.1159/000052978