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- Title
An association between psoriasis and hereditary multiple exostoses. A clue for the mapping of a psoriasis susceptibility gene?
- Authors
Rosbotham, J.L.; Trembath, R.C.; Glover, M.; Leigh, L.; Barker, J.N.W.
- Abstract
Chronic plaque psoriasis affects approximately 1.6%, of the P.K. population. Population, family and twin studies all strongly suggest an important genetic component in the pathogenesis of the disease. although genetic linkage studies have, so far, failed to identify susceptibility genes. We describe a family in which psoriasis cosegregates through three generations with a known autosomal dominant disorder, hereditary multiple exostoses IHME). A major locus for HME has recently been mapped to chromosome 8q. Observations in this family may provide a mapping clue for a psoriasis susceptibility gene.
- Subjects
PSORIASIS; GENES; BONE diseases; SKIN diseases; DIAGNOSIS; GENETICS
- Publication
British Journal of Dermatology, 1994, Vol 130, Issue 5, p671
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1994.tb13120.x