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- Title
Myeloid differentiation factor 88-dependent signalling controls bacterial growth during colonization and systemic pneumococcal disease in mice.
- Authors
Albiger, Barbara; Sandgren, Andreas; Katsuragi, Hiroaki; Meyer-Hoffert, Ulf; Beiter, Katharina; Wartha, Florian; Hornef, Mathias; Normark, Staffan; Normark, Birgitta Henriques
- Abstract
The Toll-like receptors (TLRs) and the myeloid differentiation factor 88 (MyD88) are key players in the activation of the innate immune defence during microbial infections. Using different murine infection models, we show that MyD88-dependent signalling is crucial for the activation of the innate immune defence against Streptococcus pneumoniae. Our data demonstrate that both local and systemic inflammatory response to S. pneumoniae depends on the presence of MyD88 to clear bacterial colonization of the upper respiratory tract and to prevent pulmonary and systemic infection in mice. Finally, we described a strong correlation between enhanced bacterial growth in the bloodstream of MyD88-deficient mice and the inability to lower the serum iron concentration in response to infection.
- Subjects
STREPTOCOCCUS pneumoniae; IMMUNE system; MICE; INFECTION; MICROBIAL growth; BACTERIAL growth
- Publication
Cellular Microbiology, 2005, Vol 7, Issue 11, p1603
- ISSN
1462-5814
- Publication type
Article
- DOI
10.1111/j.1462-5822.2005.00578.x