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- Title
Urinary orosomucoid 1 protein to creatinine ratio as a potential biomarker for early screening of kidney impairment in type‐2 diabetes patients.
- Authors
Wang, Huabin; Bao, Xinyu; Ma, Yongjun; Shan, Xiaoyun; Huang, Caiqun
- Abstract
Background: Early screening of diabetic kidney disease (DKD) remains a major challenge. Our aim was to evaluate the value of urinary orosomucoid 1 protein (UORM1) in early renal impairment screening in type‐2 diabetes patients. Methods: The concentration of UORM1, the UORM1‐to‐creatinine ratio (UORM1CR), the urinary albumin‐to‐creatinine ratio (ACR), the alpha‐1‐microglobulin‐to‐creatinine ratio (A1MCR) and estimated glomerular filtration rate (eGFR) were measured in 406 type‐2 diabetes patients. Any positive values for ACR, A1MCR and/or eGFR were considered as indicative of renal impairment. Results: On average, the levels of UORM1 and UORM1CR were about seven times higher in subjects with renal injury than in those without. Both UORM1 and UORM1CR, when adjusted via logarithm‐transformation, were significantly related to ACR, A1MCR and eGFR levels. The highest correlation was observed between UORM1CR and A1MCR (r = 0.85, P <.001). The cut‐off values for UORM1 (2.53 mg/L) and UORM1CR (3.69 mg/g) for the early diagnosis of kidney impairment were obtained from receiver operating characteristic curves. UORM1CR obviously had higher diagnostic efficiency corresponding to 83.26% sensitivity and 90.32% specificity than UORM1. Likewise, its sensitivity was higher than those of ACR, A1MCR and eGFR. Bad glycaemic control had the highest risk of increased UORM1CR (odds ratio [OR] = 2.81, P <.001), while high HDL‐C (high‐density lipoprotein cholesterol) decreased the risk of increased UORM1CR (OR = 0.38, P =.017). Conclusion: The UORM1CR (>3.69 mg/g) has the high diagnostic efficiency for the early screening of renal impairment in type‐2 diabetes patients. Furthermore, good glycaemic control and high HDL‐C might be protective factors against UORM1CR increase. SUMMARY AT A GLANCE: Urinary orosomucoid 1 protein could be an effective early biomarker to detect diabetic kidney disease in this cohort of 406 patients with type 2 diabetes.
- Subjects
PEOPLE with diabetes; GLYCEMIC control; BIOMARKERS; RECEIVER operating characteristic curves; DIABETIC nephropathies
- Publication
Nephrology, 2020, Vol 25, Issue 9, p667
- ISSN
1320-5358
- Publication type
Article
- DOI
10.1111/nep.13707