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- Title
Association of single nucleotide polymorphisms in the promoter region of the pro-opiomelanocortin gene ( POMC) with low bone mineral density in adult women.
- Authors
Sudo, Yoshihiro; Ezura, Yoichi; Kajita, Mitsuko; Yoshida, Hideyo; Suzuki, Takao; Hosoi, Takayuki; Inoue, Satoshi; Shiraki, Masataka; Ito, Hiromoto; Emi, Mitsuru
- Abstract
Among multiple factors influencing osteoporosis, genetic variations involved in bone-mineral metabolism can affect risks predisposing to the disease onset. Here, we studied single-nucleotide polymorphisms (SNPs) in the pro-opiomelanocortin ( POMC) gene for possible association with bone mineral density (BMD) among 384 adult Japanese women and observed significant correlation between adjusted BMD and three SNPs in the promoter region ( r>0.14, p<0.01). The most significant correlation was observed for −2353G/A ( r=−0.16, p=0.002); homozygous carriers of the major (G) allele had the highest BMD (0.405±0.054 g/cm2) while heterozygous carriers were intermediate (0.390±0.053 g/cm2) and homozygous A-allele carriers had the lowest BMDs (0.369±0.048 g/cm2). Although no association was detected between these SNPs and body weight or body mass index (BMI), significant association was detected between the −2313A/C genotype and plasma total cholesterol level ( r=−0.12, p=0.019). We propose that POMC is among the likely susceptibility genes for osteoporosis and may also be involved in dyslipidemia.
- Subjects
OSTEOPOROSIS; GENETIC polymorphisms; BONES; METABOLISM; NUCLEOTIDES; GENES
- Publication
Journal of Human Genetics, 2005, Vol 50, Issue 5, p235
- ISSN
1434-5161
- Publication type
Article
- DOI
10.1007/s10038-005-0244-x