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- Title
The prevalence and outcomes of depression in older HIV-positive adults in Northern Tanzania: a longitudinal study.
- Authors
Dua, Damneek; Stubbs, Oliver; Urasa, Sarah; Rogathe, Jane; Duijinmaijer, Ashanti; Howlett, William; Dekker, Marieke; Kisoli, Aloyce; Mukaetova-Ladinska, Elizabeta B.; Gray, William K.; Lewis, Thomas; Walker, Richard W.; Dotchin, Catherine L.; Lwezuala, Bingileki; Makupa, Philip C.; Paddick, Stella Maria
- Abstract
Studies of depression and its outcomes in older people living with HIV (PLWH) are currently lacking in sub-Saharan Africa. This study aims to investigate the prevalence of psychiatric disorders in PLWH aged ≥ 50 years in Tanzania focussing on prevalence and 2-year outcomes of depression. PLWH aged ≥ 50 were systematically recruited from an outpatient clinic and assessed using the Mini-International Neuropsychiatric Interview (MINI). Neurological and functional impairment was assessed at year 2 follow-up. At baseline, 253 PLWH were recruited (72.3% female, median age 57, 95.5% on cART). DSM-IV depression was highly prevalent (20.9%), whereas other DSM-IV psychiatric disorders were uncommon. At follow-up (n = 162), incident cases of DSM-IV depression decreased from14.2 to 11.1% (χ2: 2.48, p = 0.29); this decline was not significant. Baseline depression was associated with increased functional and neurological impairment. At follow-up, depression was associated with negative life events (p = 0.001), neurological impairment (p < 0.001), and increased functional impairment (p = 0.018), but not with HIV and sociodemographic factors. In this setting, depression appears highly prevalent and associated with poorer neurological and functional outcomes and negative life events. Depression may be a future intervention target.
- Subjects
TANZANIA; SUB-Saharan Africa; HIV-positive persons; OLDER people; LIFE change events; HIV; MENTAL depression; LONGITUDINAL method
- Publication
Journal of NeuroVirology, 2023, Vol 29, Issue 4, p425
- ISSN
1355-0284
- Publication type
Article
- DOI
10.1007/s13365-023-01140-4