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- Title
Comparison of three different definitions of low disease activity in patients with systemic lupus erythematosus and their prognostic utilities.
- Authors
Kang, Ji-Hyoun; Shin, Min-Ho; Choi, Sung-Eun; Xu, Haimuzi; Park, Dong-Jin; Lee, Shin-Seok
- Abstract
Objectives Three definitions of low-level disease activity in patients with SLE have been proposed by different groups. These include minimal disease activity (MDA), low disease activity (LDA) and the lupus low disease activity state (LLDAS). We investigated the performance of these definitions in SLE patients. Methods We recruited 299 SLE patients who were followed up annually for 4 consecutive years. We compared the three definitions of low disease activity via longitudinal analysis; we used a generalized, linear-mixed effects model and generalized estimating equations. Results The LLDAS was significantly associated with a lower SLICC/ACR damage index (β coefficient=−0.064, 95% CI: −0.129, −0.002, P =0.050), reduced flare (odds ratio = 0.090, 95% CI: 0.034, 0.239, P <0.001), an improved SF-36 physical component score (β coefficient=0.782, 95% CI: 0.046, 1.519, P =0.037), and an improved SF-36 mental component score (β coefficient=1.522, 95% CI: 0.496, 2.547, P =0.004). Neither the MDA nor the LDA were associated with these variables. Conclusion The LLDAS definition performs better than the MDA and LDA definitions, showing that LLDAS is associated with less organ damage and flare, and a better quality of life, during follow-up.
- Subjects
CONFIDENCE intervals; QUALITY of life; SYSTEMIC lupus erythematosus; SYMPTOMS; SEVERITY of illness index; DESCRIPTIVE statistics; ODDS ratio
- Publication
Rheumatology, 2021, Vol 60, Issue 2, p762
- ISSN
1462-0324
- Publication type
Article
- DOI
10.1093/rheumatology/keaa407