We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Acyl‐Imidazoles: A Privileged Ester Surrogate for Enantioselective Synthesis.
- Authors
Lauberteaux, Jimmy; Pichon, Delphine; Baslé, Olivier; Mauduit, Marc; Marcia de Figueiredo, Renata; Campagne, Jean‐Marc
- Abstract
Since the first report by Evans in asymmetric Friedel‐Crafts reactions, the use of acyl‐imidazoles has blossomed as powerful ester/amide surrogates. The imidazole scaffold indeed displays stability and special activation features allowing both better reactivity and selectivity in traditional ester/amide functionalizations: α‐(enolate chemistry), β‐(conjugate additions), α,β‐(cycloadditions) or γ/δ‐(vinylogous). An overview of the contemporary and growing interest in acyl‐imidazoles in metal‐ and organo‐catalyzed transformations (bio‐hybrid catalytic systems will be fully described in a back‐to‐back Minireview) will be highlighted. Moreover, post‐functionalization expediencies are also going to be discussed in this Minireview.
- Subjects
FRIEDEL-Crafts reaction; ESTERS; ASYMMETRIC synthesis; IMIDAZOLES; RING formation (Chemistry); ISOXAZOLIDINES
- Publication
ChemCatChem, 2019, Vol 11, Issue 23, p5705
- ISSN
1867-3880
- Publication type
Article
- DOI
10.1002/cctc.201900754