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- Title
Effect of α-lipoic acid on platelet reactivity in type 1 diabetic patients.
- Authors
Mollo R; Zaccardi F; Scalone G; Scavone G; Rizzo P; Navarese EP; Manto A; Pitocco D; Lanza GA; Ghirlanda G; Crea F; Mollo, Roberto; Zaccardi, Francesco; Scalone, Giancarla; Scavone, Giuseppe; Rizzo, Paola; Navarese, Eliano Pio; Manto, Andrea; Pitocco, Dario; Lanza, Gaetano Antonio
- Abstract
<bold>Objective: </bold>Type 1 diabetes is associated with increased platelet reactivity. We investigated whether α-lipoic acid (ALA) has any effect on platelet reactivity in these patients.<bold>Research Design and Methods: </bold>We randomly assigned 51 type 1 diabetic patients to ALA (600 mg once daily) or placebo for 5 weeks. Platelet reactivity was evaluated by the PFA-100 method and by measuring CD41 and CD62 platelet expression. C-reactive protein (CRP) and 8-iso-prostaglandin F2α serum levels also were measured.<bold>Results: </bold>Baseline variables were similar in the two groups. After treatment, closure time was longer (P = 0.006) and CD62P platelet expression was lower, both before (P = 0.002) and after (P = 0.009) ADP stimulation in the ALA group compared with the placebo group. CRP and 8-iso-prostaglandin F2α levels showed no differences between the two groups.<bold>Conclusions: </bold>Our data show that ALA reduces measures of platelet reactivity ex vivo in type 1 diabetic patients, independently of antioxidant or anti-inflammatory effects.
- Publication
Diabetes Care, 2012, Vol 35, Issue 2, p196
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/dc11-1255