We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Extensive Lower Lip Squamous Cell Carcinoma in a Fanconi Anaemia Patient and Treatment Delays during COVID-19 Pandemic.
- Authors
Sivanganam, Shobina; Abdullah, Mohd Faizal; Abdul Rahman, Shaifulizan
- Abstract
Fanconi anaemia (FA) is an autosomal recessive inherited disease that renders patients susceptible to congenital anomalies, bone marrow failures, leukaemia, and solid malignancies. FA is caused by the loss of function of at least one gene in the FA/BRCA biological pathway, which is involved in DNA repair. Patients with FA have an increased risk of developing head and neck cancer, particularly oral squamous cell carcinoma (SCC). Due to susceptibility of head and neck cancer at a very young age, relatively poor survival rate, low tolerance to oncologic interventions, and complexity of treatments, strict follow-up is mandatory to detect any changes or recurrence of SCC in the head and neck region in FA patients. Surgery is the mainstay of treatment, but adjuvant therapy should be instituted when needed. This short report describes a rare case of lower lip SCC in FA and its management. It also highlights the impact of the COVID-19 pandemic on healthcare practices.
- Subjects
FANCONI'S anemia; HEAD &; neck cancer; SQUAMOUS cell carcinoma; COVID-19 pandemic; ANEMIA treatment; TREATMENT delay (Medicine)
- Publication
Case Reports in Oncology, 2022, Vol 15, Issue 3, p848
- ISSN
1662-6575
- Publication type
Case Study
- DOI
10.1159/000526698