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- Title
White Matter Microstructure Predicts Autistic Traits in Attention-Deficit/Hyperactivity Disorder.
- Authors
Cooper, Miriam; Thapar, Anita; Jones, Derek
- Abstract
Traits of autism spectrum disorder (ASD) in children with attention-deficit/hyperactivity disorder (ADHD) have previously been found to index clinical severity. This study examined the association of ASD traits with diffusion parameters in adolescent males with ADHD (n = 17), and also compared WM microstructure relative to controls (n = 17). Significant associations ( p < 0.05, corrected) were found between fractional anisotropy/radial diffusivity and ASD trait severity (positive and negative correlations respectively), mostly in the right posterior limb of the internal capsule/corticospinal tract, right cerebellar peduncle and the midbrain. No case-control differences were found for the diffusion parameters investigated. This is the first report of a WM microstructural signature of autistic traits in ADHD. Thus, even in the absence of full disorder, ASD traits may index a distinctive underlying neurobiology in ADHD.
- Subjects
DIAGNOSTIC imaging equipment; ALGORITHMS; ATTENTION-deficit hyperactivity disorder; AUTISM; BRAIN; INTERVIEWING; HANDEDNESS; QUESTIONNAIRES; RESEARCH funding; COMORBIDITY; PREDICTIVE tests; CASE-control method; DATA analysis software; DESCRIPTIVE statistics; MANN Whitney U Test; ADOLESCENCE
- Publication
Journal of Autism & Developmental Disorders, 2014, Vol 44, Issue 11, p2742
- ISSN
0162-3257
- Publication type
Article
- DOI
10.1007/s10803-014-2131-9