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- Title
Extracranial-Intracranial Bypass Surgery for Stroke Prevention in Hemodynamic Cerebral Ischemia: The Carotid Occlusion Surgery Study Randomized Trial.
- Authors
Powers, William J.; Clarke, William R.; Grubb Jr., Robert L.; Videen, Tom O.; Adams Jr., Harold P.; Derdeyn, Colin P.
- Abstract
The article discusses a study that tests the hypothesis that extracranial-intracranial (EC-IC) bypass surgery, incorporated to best medical therapy, decreases subsequent ipsilateral ischemic stroke in patients with symptomatic atherosclerotic internal carotid artery occlusion (AICAO) and hemodynamic cerebral ischemia. Results reveal that EC-IC bypass surgery failed to provide an overall benefit on 2-year stroke recurrence. The 30-day postoperative morbidity and mortality of 15% was reportedly not statistically significantly different from the rate of 12% from the EC-IC Bypass Trial. The Carotid Occlusion Surgery Study was terminated based on a futility analysis that revealed a 29% chance of showing a statistically significant benefit for surgery if taken to completion.
- Subjects
CEREBRAL revascularization; CORONARY artery bypass; THERAPEUTICS; CEREBROVASCULAR disease; CAROTID artery diseases; CEREBRAL ischemia
- Publication
JAMA: Journal of the American Medical Association, 2011, Vol 306, Issue 18, p1983
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.2011.1610