We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
IgA deposition in the skin of patients with alcoholic liver disease.
- Authors
Saklayen, Mohammad G.; Schroeter, Arnold L.; Nafz, Mary Ann; Jalil, Khalid
- Abstract
In patients with alcoholic liver disease, IgA deposits are often found in the liver kidneys and skin. The present study was undertaken to determine the specificity, sensitivity and characteristics of IgA deposition in the skin of a group of alcoholic patients without overt liver disease, and compare these with findings in non-alcoholic cirrhotics, Twenty-six out of 28 patients with alcoholic cirrhosis had IgA deposition in the skin. In contrast, only 6 out of it patients who were alcoholic without any clinical liver disease and 3 out of 13 patient with non-alcoholic cirrhosis of the liver had IgA deposition. In the control group, only 1 out of 52 patients with various dermatoses (excluding IgA. dermatoses) had this lgA deposition. Unlike other IgA dermatoses, such as Henoch-Schoenlein purpura or dermatitis herpetiformis, IgA deposition in alsocholic liver disease is characterized by its presence in the basement membrane of the eccrine secretory coils. This particular pattern of IgA deposition can be helpful in the diagnosis of alcoholic liver disease or alcoholism since the specificity is 100% with a sensitivity of 75%.
- Subjects
CIRRHOSIS of the liver; SKIN diseases; IMMUNOGLOBULIN A; PATIENTS; ALCOHOL drinking; PURPURA (Pathology); DERMATITIS herpetiformis
- Publication
Journal of Cutaneous Pathology, 1996, Vol 23, Issue 1, p12
- ISSN
0303-6987
- Publication type
Article
- DOI
10.1111/j.1600-0560.1996.tb00771.x