We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Bidirectional relationship between renal function and periodontal disease in older Japanese women.
- Authors
Yoshihara, Akihiro; Iwasaki, Masanori; Miyazaki, Hideo; Nakamura, Kazutoshi
- Abstract
Objectives The purpose of this study was to evaluate the reciprocal effects of chronic kidney disease ( CKD) and periodontal disease. Material and Methods A total of 332 postmenopausal never smoking women were enrolled, and their serum high-sensitivity C-reactive protein, serum osteocalcin and serum cystatin C levels were measured. Poor renal function was defined as serum cystatin C > 0.91 mg/l. Periodontal disease markers, including clinical attachment level and the periodontal inflamed surface area ( PISA), were also evaluated. Logistic regression analysis was conducted to evaluate the relationships between renal function and periodontal disease markers, serum osteocalcin level and hs CRP level. The prevalence-rate ratios ( PRRs) on multiple Poisson regression analyses were determined to evaluate the relationships between periodontal disease markers and serum osteocalcin, serum cystatin C and serum hs CRP levels. Results On logistic regression analysis, PISA was significantly associated with serum cystatin C level. The odds ratio for serum cystatin C level was 2.44 ( p = 0.011). The PRR between serum cystatin C level and periodontal disease markers such as number of sites with clinical attachment level ≥6 mm was significantly positive (3.12, p < 0.001). Similar tendencies were shown for serum osteocalcin level. Conclusion This study suggests that CKD and periodontal disease can have reciprocal effects.
- Subjects
JAPAN; CHRONIC kidney failure complications; BONE resorption; C-reactive protein; CONFIDENCE intervals; EPIDEMIOLOGICAL research; KIDNEY function tests; PERIODONTAL disease; PERIODONTIUM examination; PROBABILITY theory; PROTEINS; RESEARCH funding; T-test (Statistics); COMORBIDITY; MULTIPLE regression analysis; SYMPTOMS; POSTMENOPAUSE; DATA analysis software; DESCRIPTIVE statistics; OSTEOCALCIN; ODDS ratio; MANN Whitney U Test; DISEASE complications
- Publication
Journal of Clinical Periodontology, 2016, Vol 43, Issue 9, p720
- ISSN
0303-6979
- Publication type
Article
- DOI
10.1111/jcpe.12576