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- Title
Depressive Symptoms and Quality of Life Associated With the Use of Monoclonal Antibodies in Breast Cancer Treatment.
- Authors
Cáceres, Macarena C.; Pérez-Civantos, Demetrio; Guerrero-Martín, Jorge; Nadal Delgado, Marta; López Jurado, Casimiro; Durán-Gómez, Noelia
- Abstract
OBJECTIVES: To assess the relationship between (a) chemotherapy and monoclonal antibody (mAb) treatments and (b) depressive symptoms and quality of life (QOL) in patients with breast cancer. SAMPLE & SETTING: 182 women with breast cancer in Spain who were undergoing chemotherapy with or without mAbs. METHODS & VARIABLES: An observational, cross-sectional study was carried out. The European Organisation for Research and Treatment of Cancer (EORTC) QOL Questionnaire-Core 30 and the EORTC QOL Questionnaire-Breast Cancer were used to assess QOL. Patients were screened for depressive symptoms using the Beck Depression Inventory-II. RESULTS: No relationship was found between the use of mAbs with chemotherapy and QOL, except for incidence of diarrhea. However, depressive symptoms had a negative and highly significant influence on the majority of the QOL parameters. IMPLICATIONS FOR NURSING: The presence of depressive symptoms negatively affects QOL. Used concurrently, mAbs and chemotherapy do not negatively influence QOL, but some adverse effects, such as diarrhea, are common.
- Subjects
SPAIN; THERAPEUTIC use of monoclonal antibodies; STATISTICS; SCIENTIFIC observation; HUMAN research subjects; ANALYSIS of variance; CANCER chemotherapy; CROSS-sectional method; MULTIVARIATE analysis; ONE-way analysis of variance; MONOCLONAL antibodies; CANCER patients; PSYCHOLOGICAL tests; INFORMED consent (Medical law); TUMOR classification; MENTAL depression; QUALITY of life; QUESTIONNAIRES; CHI-squared test; DESCRIPTIVE statistics; RESEARCH funding; STATISTICAL sampling; ELECTRONIC health records; DATA analysis; DATA analysis software; BREAST tumors
- Publication
Oncology Nursing Forum, 2021, Vol 48, Issue 5, p535
- ISSN
0190-535X
- Publication type
Article
- DOI
10.1188/21.ONF.535-545