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- Title
Cortical Alterations in Medication-Overuse Headache.
- Authors
Riederer, Franz; Schaer, Marie; Gantenbein, Andreas R.; Luechinger, Roger; Michels, Lars; Kaya, Marihan; Kollias, Spyridon; Sándor, Peter S.
- Abstract
Objective Using surface-based morphometry we aimed to provide a detailed examination of cortical alterations in medication-overuse headache (MOH), by disentangling between altered cortical thickness and gyrification (folding). Background In MOH, pain modulation is probably dysfunctional at the cortical and subcortical level, resulting in a disequilibrium between pain inhibition and facilitation. Both increased and decreased cortical volumes have been reported in individuals with MOH. There is however no detailed examination to date that distinguishes between altered cortical thickness and gyrification. Such distinction would help to identify the nature and timing of neurodevelopmental mechanisms at play in affected individuals. Methods We investigated cortical thickness and gyrification in 29 patients with MOH according to International Headache Society criteria and 29 age- and gender-matched controls, using high-resolution structural MRIs of the brain analyzed with FreeSurfer. This is a secondary analysis of data from a previously published voxel-based morphometry study. Results In patients with MOH compared to controls, reduced cortical thickness was observed in the left prefrontal cortex. We also observed higher local gyrification in one cluster extending from the fusiform cortex to adjacent medial temporal regions, and in another cluster in the right occipital pole. Higher gyrification in the right occipital pole predicted poor response after detoxification. Conclusions Corroborating previous volumetric results, our study adds information on the putative neurobiological mechanisms involved in MOH, suggesting neurodevelopmental changes in MOH.
- Subjects
SWITZERLAND; CEREBRAL cortex; COMPARATIVE studies; STATISTICAL correlation; DIGITAL image processing; LONGITUDINAL method; MAGNETIC resonance imaging; MIGRAINE; PAIN; PROBABILITY theory; RESEARCH funding; STATISTICAL hypothesis testing; MATHEMATICAL variables; SECONDARY analysis; RETROSPECTIVE studies; DIARY (Literary form); DESCRIPTIVE statistics
- Publication
Headache: The Journal of Head & Face Pain, 2017, Vol 57, Issue 2, p255
- ISSN
0017-8748
- Publication type
Article
- DOI
10.1111/head.12993