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- Title
B in TB: B Cells as Mediators of Clinically Relevant Immune Responses in Tuberculosis.
- Authors
Rao, Martin; Valentini, Davide; Poiret, Thomas; Dodoo, Ernest; Parida, Shreemanta; Zumla, Alimuddin; Brighenti, Susanna; Maeurer, Markus
- Abstract
The protective role of B cells and humoral immune responses in tuberculosis infection has been regarded as inferior to cellular immunity directed to the intracellular pathogen Mycobacterium tuberculosis. However, B-cell-mediated immune responses in tuberculosis have recently been revisited in the context of B-cell physiology and antigen presentation. We discuss in this review the diverse functions of B cells in tuberculosis, with a focus on their biological and clinical relevance to progression of active disease. We also present the peptide microarray platform as a promising strategy to discover unknown antigenic targets of M. tuberculosis that could contribute to the better understanding of epitope focus of the humoral immune system against M. tuberculosis.
- Subjects
TUBERCULOSIS -- Immunological aspects; B cells; IMMUNE response; CELLULAR immunity; DISEASE progression; EPITOPES
- Publication
Clinical Infectious Diseases, 2015, Vol 61, pS225
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/civ614