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- Title
Increased HIV-1 Activity in Anal High-Grade Squamous Intraepithelial Lesions Compared With Unaffected Anal Mucosa in Men Who Have Sex With Men.
- Authors
Pollakis, Georgios; Richel, Olivier; Vis, Joost D.; Prins, Jan M.; Paxton, William A.; de Vries, Henry J. C.
- Abstract
HIV-1–infected individuals with anal high-grade squamous intraepithelial lesions have higher HIV-1 activity within the lesion compared with neighboring healthy tissue. The results indicate that the number of infected cells increases with resultant heightened viral activity at the mucosa.We studied 3 patients with focal intra-anal tissue high-grade squamous intraepithelial lesions (HSILs). All had increased human immunodeficiency virus type 1 (HIV-1) RNA and DNA in lesions compared with that in healthy mucosa. HIV-1 RNA and HIV-1 episomal DNA were indicative of ongoing viral replication, more so in anal HSILs.
- Subjects
MEN who have sex with men; HIV-positive persons; HIV; MUCOUS membranes; EPITHELIAL cells; ANAL disease diagnosis; DISEASES
- Publication
Clinical Infectious Diseases, 2014, Vol 58, Issue 11, p1634
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciu133